Methanol → HCID 66961382, compound

HRID 2247496Notes

Reaction equation

HRID 2247496 reaction equation
CO.[C:3]([O:7][C:8]([N:10]1[CH2:16][CH2:15][CH2:14][C:13]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)(O)[CH2:12][CH2:11]1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>[H][H].[Pd]>[C:3]([O:7][C:8]([N:10]1[CH2:16][CH2:15][CH2:14][CH:13]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[CH2:12][CH2:11]1)=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 887MethanolHCID 66961012HCID 66961012, compound

Product 1

HCID 66961382HCID 66961382, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 178418361HCID 178418361, compoundSolvent

Procedure

To a methanol (10 mL) solution of 4-(4-fluorophenyl)-4-hydroxyazepane-1-carboxylic acid tert-butyl ester (100 mg) obtained in Example 352, 10% Pd—C (100 mg) was added, and the reaction solution was agitated in hydrogen stream at room temperature for 1 hour. Suction filtration of the reaction solution was carried out using celite after the reaction ended, and the filtrate was concentrated under reduced pressure. The obtained crude product of 4-(4-fluorophenyl)azepane-1-carboxylic acid tert-butyl ester was used for the next reaction, without further purifying.

Workup

  1. filtrationSuction filtration of the reaction solution
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0789a568ccd34d769d4125efdf1d2e77
Source dataset
uspto-grants-2010_03
Patent number
US07687640B2

Reaction notes

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