HCID 86602485, compound → 5-Morpholin-4-yl-indan-1-ylamine

HRID 2247561Notes

Reaction equation

HRID 2247561 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[C:12](=[N:16]O)[CH2:11][CH2:10]3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>[C].[Pd].C(O)C>[N:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[CH:12]([NH2:16])[CH2:11][CH2:10]3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 86602485HCID 86602485, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 669617445-Morpholin-4-yl-indan-1-ylamineYield 63.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An ethanol (20 mL) suspension of 5-morpholin-4-yl-indan-1-on-oxime (2.76 g) and 10% palladium carbon (48% water content, 1.0 g) was agitated at room temperature under 0.4 MPa hydrogen atmosphere for 6 hours. After filtering the reaction solution and condensing the filtrate under reduced pressure, 1.64 g of the title compound was obtained by purifying the obtained residue by silica gel chromatography (Carrier: Chromatorex™ NH, elution solvent: heptane-ethyl acetate system->ethyl acetate-methanol system). The physical properties of the compound are as follows.

Workup

  1. filtrationAfter filtering
  2. customthe reaction solution and condensing the filtrate under reduced pressure

Sources & evidence

ORD record
ord-b6b58ca36775450b825563eccc623e38
Source dataset
uspto-grants-2010_03
Patent number
US07687640B2

Reaction notes

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