Sodium Hydroxide → 1-[(5-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methyl]azetidine-3-carboxylic acid

Participants

Reaction Steps

The title compound (60 mg) was synthesized in a yield of 53% as a white crystalline solid by conducting the similar reaction to that mentioned in Example 3 (3e) using ethyl 1-[(5-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methyl]azetidine-3-carboxylate (0.12 g, 0.23 mmol) that was obtained in Example 4 (4d) and a 1N aqueous solution of sodium hydroxide (0.69 ml, 0.69 mmol).

Provenance & Evidence