Sodium Hydroxide → 1-({5-[5-(4-Phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid

Participants

Reaction Steps

The title compound (69 mg) was synthesized in a yield of 80% as a white crystalline solid by conducting the similar reaction to that mentioned in Example 3 (3e) using ethyl 1-({5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylate (90 mg, 0.20 mmol) that was obtained in Example 5 (5b) and a 1N aqueous solution of sodium hydroxide (0.60 ml, 0.60 mmol).

Provenance & Evidence