1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 68525625, compound

Participants

Reaction Steps

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 5 (5a) using 4-benzylbenzoic acid (0.12 g, 0.55 mmol), 1-hydroxybenzotriazole (88 mg, 0.65 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.12 g, 0.60 mmol), 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-N′-hydroxythiophene-3-carboximidamide (0.14 g, 0.5 mmol) that was obtained in Example 3 (3b), and tetrabutylammonium fluoride (a 1.0 M solution in tetrahydrofuran, 1.0 ml, 1.0 mmol). Subsequently, the crude product of the title compound thus obtained was purified by recrystallization from a mixed solvent of ethyl acetate and hexane to afford the title compound (99 mg) in a yield of 57% as a white crystalline solid.

Provenance & Evidence