Sodium Hydroxide → 1-({4-[5-(4-Benzylphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid

Participants

Reaction Steps

The title compound (67 mg) was synthesized in a yield of 86% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using ethyl 1-({4-[5-(4-benzylphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylate (82 mg, 0.18 mmol) that was obtained in Example 6 (6b), and a 1N aqueous solution of sodium hydroxide (0.54 ml, 0.54 mmol).

Provenance & Evidence