Hydroxylamine → 4-{[t-Butyl(dimethyl)silyl]oxy}-N'-hydroxy-4,5,6,7-tetrahydro-1-benzofuran-2-carboximidamide

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Reaction Steps

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 1 (1d) using 4-{[t-butyl(dimethyl)silyl]oxy}-4,5,6,7-tetrahydro-1-benzofuran-2-carbonitrile (3.0 g, 11 mmol) that was obtained in Example 7 (7c) and a 40% aqueous solution of hydroxylamine (3.0 ml). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (3:7) as the eluent to afford the title compound (2.7 g) in a yield of 82% as a white crystalline solid.

Provenance & Evidence