Oxalic Acid → 1-{2-[5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl]-4,5,6,7-tetrahydro-1-benzofuran-4-yl}azetidine-3-carboxylic acid

Participants

Reaction Steps

The title compound (13 mg) was synthesized in a yield of 50% as a white crystalline solid by conducting the similar reaction to that mentioned in Example 3 (3e) using ethyl 1-{2-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-4,5,6,7-tetrahydro-1-benzofuran-4-yl}azetidine-3-carboxylate (25 mg, 0.056 mmol) that was obtained in Example 7 (7f), a 1N aqueous solution of sodium hydroxide (0.17 ml, 0.17 mmol), and oxalic acid (3 mg, 0.028 mmol).

Provenance & Evidence