Triethylamine → HCID 68522073, compound

Participants

Reaction Steps

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 1 (1c) using 4-{[t-butyl(dimethyl)silyl]oxy}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxaldehyde (4.4 g, 15.3 mmol) that was obtained in Example 8 (8c), hydroxylamine hydrochloride (1.1 g, 16 mmol), triethylamine (4.1 ml, 30 mmol), and N,N′-dicyclohexylcarbodiimide (3.4 g, 16 mmol). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:9) as the eluent to afford the title compound (4.1 g) in a yield of 94% as a colourless oily product.

Provenance & Evidence