Sodium Hydroxide → 1-({4-Ethyl-5-[5-(3-fluoro-4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid

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Reaction Steps

The title compound (0.11 g) was synthesized in a yield of 77% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-({4-ethyl-5-[5-(3-fluoro-4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylate (0.15 g, 0.30 mmol) that was obtained in Example 14 (14b) and a 1 N aqueous solution of sodium hydroxide (0.9 mL, 0.9 mmol).

Provenance & Evidence