HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dihydroxy-4-methylquinoline → 4-Methyl-6-{3-[4-(4-tert.-butylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dihydroxy-4-methylquinoline | HCID 600288 | — |
| Reactant | 3-[4-(4-Tert.-butylbenzyl)-piperazin-1-yl]-propyl chloride | HCID 23330459 | — |
| Product | 4-Methyl-6-{3-[4-(4-tert.-butylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline | HCID 23330436 | — |
Reaction Steps
In a manner analogous to that described in Example 5, by the reaction of 4-methyl-6-hydroxy-2-oxo-1,2-dihydroquinoline with 3-[4-(4-tert.-butylbenzyl)-piperazin-1-yl]-propyl chloride, there is obtained 4-methyl-6-{3-[4-(4-tert.-butylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline which, after recrystallization from ethyl acetate, melts at 171°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04234585 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-78419ef3a4444d4bb3e97808cbbfd315 |
| Source note | uspto-grants-1980_11 |