HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dihydroxy-4-methylquinoline → 4-Methyl-6-{3-[4-(4-methylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dihydroxy-4-methylquinoline | HCID 600288 | — |
| Reactant | 3-[4-(4-Methylbenzyl)-piperazin-1-yl]-propyl chloride | HCID 20153193 | — |
| Product | 4-Methyl-6-{3-[4-(4-methylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline | HCID 23330453 | — |
Reaction Steps
4-Methyl-6-hydroxy-2-oxo-1,2dihydroquinoline is reacted with 3-[4-(4-methylbenzyl)-piperazin-1-yl]-propyl chloride in a manner analogous to that described in Example 5. There is obtained 4-methyl-6-{3-[4-(4-methylbenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline which, after recrystallization from diethyl ether, melts at 162°-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04234585 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-0e93f41cd52c4c9799366a4f830ad429 |
| Source note | uspto-grants-1980_11 |