Carbon tetrabromide → HCID 68524254, compound

Participants

Reaction Steps

The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 1 (1f) using (4-ethyl-5-{5-[4-(2-methoxyphenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methanol (0.14 g, 0.35 mmol) that was obtained in Example 21 (21b), carbon tetrabromide (0.17 g, 0.53 mmol), triphenylphosphine (0.14 g, 0.53 mmol), methyl 3-azetidinecarboxylate hydrochloride (80 mg, 0.53 mmol), and N,N-diisopropylethylamine (0.18 mL, 1.1 mmol). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (2:5 to 1:2) as the eluent to afford the title compound (89 mg) in a yield of 50% as a colourless oily product.

Provenance & Evidence