Water → HCID 68525955, compound

Participants

Reaction Steps

To a solution of 3-{4-ethyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-thienyl}-5-(4-phenoxyphenyl)-1,2,4-oxadiazole (0.25 g, 0.54 mmol) that was obtained in Example 22 (22e) in ethanol (5 ml) was added pyridinium p-toluenesulfonate (0.014 g, 0.54 mmol) with stirring, and the resulting mixture was stirred at 60° C. for 4 hours. After stirring, the reaction mixture was poured into water (20 ml) to quench the reaction and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. After filtration, the filtrate was evaporated in vacuo to afford the title compound (0.19 g) in a yield of 92% as a crystalline white solid.

Provenance & Evidence