Hydroxylamine → 6-({[t-Butyl(dimethyl)silyl]oxy}methyl)-N'-hydroxypyridine-3-carboximidamide

Participants

Reaction Steps

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 1 (1d) using 6-({[t-butyl(dimethyl)silyl]oxy}methyl)nicotinonitrile (2.0 g, 8.1 mmol) that was obtained in Example 23 (23b) and a 40% aqueous solution of hydroxylamine (1 ml). Subsequently, the crude product of the title compound thus obtained was purified by recrystallization from a mixed solvent of ethyl acetate and hexane (1:9) to afford the title compound (2.1 g) in a yield of 94% as a white crystalline solid.

Provenance & Evidence