Sodium Hydroxide → 1-({5-[5-(3-Chloro-4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-6-ethylpyridin-2-yl}methyl)azetidine-3-carboxylic acid

Participants

Reaction Steps

The title compound (0.10 g) was synthesized in a yield of 71% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-({5-[5-(3-chloro-4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]-6-ethylpyridin-2-yl}methyl)azetidine-3-carboxylate (0.15 g, 0.32 mmol) that was obtained in Example 25 (25d) and a 1 N aqueous solution of sodium hydroxide (0.96 mL, 0.96 mmol).

Provenance & Evidence