Tetrahydrofuran → (4-Bromo-2-methylphenyl)methanol

Participants

Reaction Steps

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 24 (24e) using 4-bromo-2-methylbenzoic acid (4.0 g, 19 mmol) and a 1.0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (20 ml, 20 mmol). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:19 to 3:2) as the eluent to afford the title compound (3.7 g) in a yield of 99% as a colourless oily product.

Provenance & Evidence