(4-Bromo-2-methylphenyl)methanol → 4-Bromo-2-methylbenzaldehyde

HRID 2247768Notes

Reaction equation

HRID 2247768 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH3:10])[CH:3]=1.FC1C=C(C2ON=C(C3SC(CN4CC(C(OC)=O)C4)=CC=3C)N=2)C=CC=1OC1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([CH3:10])[CH:3]=1

Participants

3

Reactant 2

HCID 22280088(4-Bromo-2-methylphenyl)methanolHCID 68525875Methyl 1-({5-[5-(3-fluoro-4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-4-methyl-2-thienyl}methyl)azetidine-3-carboxylate

Product 1

HCID 135551504-Bromo-2-methylbenzaldehyde

Procedure

The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 24 (24f) using (4-bromo-2-methylphenyl)methanol (3.7 g, 19 mmol) that was obtained in Example 27 (27a) and pyridinium dichromate (11g, 28 mmol). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:19 to 1:4) as the eluent to afford the title compound (2.4 g) in a yield of 64% as a colourless oily product.

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-dd78867db45b4fce8df324a5a013e0dd
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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