Hydrogen Peroxide → HCID 53775306, compound

Participants

Reaction Steps

3.4 g (0.05 mol) of 50% strength hydrogen peroxide were added to a solution of 14.2 g (0.05 mol) of N,N-dimethyl-carbamic acid O-(2-methylthiomethyl-5-iso-propyl-6-methyl-pyrimidin-4-yl) ester in 50 ml of glacial acetic acid at 5°-10° C. The mixture was subsequently stirred at room temperature for 6 hours and the solvent was then distilled off in vacuo. The residue was dissolved in 100 ml of methylene chloride and the methylene chloride solution was washed with a solution of 10 g of potassium carbonate in 15 ml of water. The organic phase was separated off and dried over sodium sulphate. The solvent was then distilled off in vacuo. 11 g (74% of theory) of N,N-dimethyl-carbamic acid O-(2-methylsulphinylmethyl-5-iso-propyl-6-methyl-pyrimidin-4-yl) ester were thus obtained in the form of beige crystals with a melting point of 80° C.

Provenance & Evidence