Phosphorus oxychloride → HCID 86737337, compound

Participants

Reaction Steps

A mixture of 121 g of ethyl 8-hydroxy-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate (0.39 mol, prepared according to the procedure of J. Med. Chem., Vol. 11, 162 (1968)) and 500 ml of phosphorus oxychloride is refluxed for 7 to 8 hours. Three quarters of the excess phosphorus oxychloride is then removed, the residue is poured onto ice, alkalized with concentrated aqueous ammonia, and the solid product is filtered off, washed with water and dried at 60° C. Yield 108.2 g (99%), m.p. 103° C.

Provenance & Evidence