Hydrochloric Acid → HCID 88770249, compound

Participants

Reaction Conditions

Reaction Steps

56 g of Ethyl 5-chloro-1,3-dioxolo[4,5-g]quinoline-7-carboxylate (0.2 mol) are dissolved in 400 ml of anhydrous tetrahydrofuran. Nitrogen is passed through the flask and while stirring and cooling to -5° C., 5.7 g of lithium aluminum hydride are added a bit at a time in order to keep the reaction temperature below 0° C. Stirring is continued for an additional 2.5 hours. Then 360 ml of aqueous hydrochloric acid (3 N) are added while keeping the reaction temperature below 10° C. The precipitated title compound (40.5 g) is recrystallized from aqueous hydrochloric acid (3 N). Yield 38.1 g (70%), m.p. >300° C.

Provenance & Evidence