Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → Methyl N-Boc-8-amino-2E-octenoate

Participants

Reaction Steps

A solution of 35.28 g (105.5 mmole) methyl (triphenylphosphoranylidene)acetate in 70 mL methylene chloride was added to a solution of 11.36 g (52.76 mmoles) of (7) in 20 mL methylene chloride. After 2 h at room temperature, the solution was concentrated in vacuo to remove most of the solvent and the residue was diluted with ether. The solid was removed by filtration and the filtrate was concentrated and the residue chromatographed (Flash, hexane - ethyl acetate 7:3). The product fraction amounted to 10.7 g of a colorless oil (8).

Provenance & Evidence