Lawesson's reagent → HCID 10426545, compound

Participants

Reaction Steps

A suspension comprising 5.5 g of 1-[4-(diethylamino)benzenesulphonyl]-2-piperidinone and 3.74 g of Lawesson reagent in 80 cm3 of ethylene glycol dimethyl ether is heated to reflux for 1 hour. The mixture is allowed to return to room temperature and is then evaporated to dryness. The residue is chromatographed on silica (eluant: ethyl acetate/n-hexane, 1:1) and 4 g of product (m.p. 135°-140° C.) are obtained, which product is purified by 3 successive crystallizations in ethanol. 2 g of expected pure product are obtained.

Provenance & Evidence