Sodium Acetate → HCID 11722937, compound

HRID 2247827Notes

Reaction equation

HRID 2247827 reaction equation
[CH2:1]([N:3]([CH2:20][CH3:21])[C:4]1[CH:9]=[CH:8][C:7]([S:10](CCCCC(O)=O)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2].[C:22]([O-:25])(=O)[CH3:23].[Na+]>C(OC(=O)C)(=O)C>[CH2:20]([N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[CH:6][C:7]([S:10]([N:3]2[CH2:4][CH2:5][CH2:6][CH2:23][C:22]2=[O:25])(=[O:11])=[O:12])=[CH:8][CH:9]=1)[CH3:21]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 19815887HCID 19815887, compound

Product 1

HCID 11722937HCID 11722937, compoundYield 121.2%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

2 g of product obtained in Stage A are heated to reflux for 2 hours with 2 g of sodium acetate in 20 cm3 of acetic anhydride. The mixture is cooled to room temperature and evaporated to dryness, the residue is taken up in a mixture of chloroform and water, the organic phase is separated and dried and, after removal of the solvents, 1.8 g of expected crude product are obtained. M.p. 118°-120° C. After crystallization in isopropanol, 1.2 g of pure product are obtained. M.p. 122°-123° C.

Workup

  1. customevaporated to dryness
  2. additionthe residue is taken up in a mixture of chloroform and water
  3. customthe organic phase is separated
  4. customdried
  5. customafter removal of the solvents, 1.8 g of expected crude product
  6. customare obtained
  7. customAfter crystallization in isopropanol

Sources & evidence

ORD record
ord-c30e2285b2ae4cd89b5e17fac8df5d61
Source dataset
uspto-grants-1991_08
Patent number
US05037822

Reaction notes

Loading…