反应详情

To a solution of 4.3 g. (0.017 mole) 1-hydroxy-4-benzyloxynaphthalene in 15 ml. (0.19 mole) epichlorohydrin, which is heated to its boiling point while stirring, is carefully added dropwise 3.7 ml. 5M aqueous sodium hydroxide solution (0.0187 mole). The apparatus used for carrying out the reaction is equipped with a water separator so that the water distils off azeotropically from the reaction mixture with epichlorohydrin. After distilling off the theoretical amount of water, the reaction mixture is further heated under reflux for 1 hour while stirring, thereafter mixed with 50 ml. toluene, filtered off from inorganic components and the solution evaporated on a rotary evaporator. The product obtained is used for the next reaction step without further purification. Yield 6.1 g.

1. additionis carefully added dropwise 3.7 ml
2. customdistils off azeotropically from the reaction mixture with epichlorohydrin
3. distillationAfter distilling off the theoretical amount of water
4. temperaturethe reaction mixture is further heated
5. temperatureunder reflux for 1 hour
6. stirringwhile stirring
7. additionmixed with 50 ml
8. filtrationtoluene, filtered off from inorganic components
9. customthe solution evaporated on a rotary evaporator
10. customThe product obtained
11. customis used for the next reaction step without further purification