HCID 19815963, compound → HCID 19815891, compound

Participants

Reaction Steps

A mixture of 4-(5-hydroxymethyl-2-furyl)-2-methyl-3-(2-morpholinoethylcarbamoyl)-6-phenylpyridine (4.4 g) and activated manganese dioxide (26 g) in ethyl acetate (100 ml) was refluxed for 3 hours under stirring. Manganese dioxide was filtered off and the filtrate was evaporated in vacuo and the residue was subjected to column chromatography on silica gel. The column was eluted with a mixture of ethyl acetate and tetrahydrofuran (7:3 V/V) and the fraction was evaporated in vacuo. The residue was crystallized from a mixture of ethyl acetate and diisopropyl ether to give 4-(5-formyl-2-furyl)-2-methyl-3-(2-morpholinoethylcarbamoyl)-6-phenylpyridine (1.2 g).

Provenance & Evidence