Acetic Anhydride → HCID 14723097, compound

HRID 2247882Notes

Reaction equation

HRID 2247882 reaction equation
[CH2:1]([N:4]1[C@H:18]2[C@@H:8]([C:9]3[CH:10]=[CH:11][CH:12]=[C:13]4[C:19]=3[C:16]([CH2:17]2)=[C:15]([CH2:20][OH:21])[NH:14]4)[CH2:7][C@H:6]([NH:22][C:23](=[O:29])[N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])[CH2:5]1)[CH:2]=[CH2:3].[C:30](OC(=O)C)(=[O:32])[CH3:31]>N1C=CC=CC=1>[C:30]([O:21][CH2:20][C:15]1[NH:14][C:13]2[C:19]3[C:16]=1[CH2:17][C@@H:18]1[C@@H:8]([C:9]=3[CH:10]=[CH:11][CH:12]=2)[CH2:7][C@H:6]([NH:22][C:23](=[O:29])[N:24]([CH2:25][CH3:26])[CH2:27][CH3:28])[CH2:5][N:4]1[CH2:1][CH:2]=[CH2:3])(=[O:32])[CH3:31]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 14723085HCID 14723085, compound

Product 1

HCID 14723097HCID 14723097, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

213.6 mg (0.54 mmol) of 3-(6-allyl-2-hydroxymethyl-8α-ergolinyl)-1,1-diethylurea is dissolved in 5 ml of pyridine and mixed with 10 ml (0.11 mol) of acetic anhydride. After stirring for 2 hours at room temperature, the reaction mixture is added to ice, stirred for 1 hour and worked up in the way indicated above.

Workup

  1. additionthe reaction mixture is added to ice
  2. stirringstirred for 1 hour

Sources & evidence

ORD record
ord-cd867dc8c43c4cd783abf53a79fef3f7
Source dataset
uspto-grants-1991_08
Patent number
US05037832

Reaction notes

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