HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2247886Generated: October 30, 2026
Hydrochloric Acid → 6-benzoyl-3,4-dihydro-2(1H)-quinazolinone
https://huagongshe.com/reaction/2247886
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 1,2,3,4-Tetrahydroquinazolin-2-one | HCID 12360756 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-benzoyl-3,4-dihydro-2(1H)-quinazolinone | HCID 19816037 | 76.4% |
Reaction Steps
To a vigorously stirred amount of 45 parts of aluminum chloride were added dropwise 7.05 parts of N,N-dimethylformamide. After stirring for 5 min. at 70° C., there were added 5 parts of benzoyl chloride and, dropwise, 4.7 parts of 3,4-dihydro-2(1H)-quinazolinone. Stirring was continued for 2 hours at 70° C. The reaction mixture was poured into ice-water and there were added 63.5 parts of HCl. The precipitate was filtered off and recrystallized from 2-methoxyethanol, yielding 6.5 parts (76.4%) of 6-benzoyl-3,4-dihydro-2(1H)-quinazolinone; mp. 264.8° C. (interm. 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05037829 |
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| Source dataset | uspto-grants-1991_08 |
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| ORD ID | ord-38053b881e014e169f8a5f7fcffe0981 |
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| Source note | uspto-grants-1991_08 |
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