Thionyl Chloride → HCID 19816035, compound

Participants

Reaction Steps

A mixture of 3 parts of intermediate 27, namely 3,4-dihydro-6-[hydroxy(3-pyridinyl)methyl]-2(1H)-quinazolinone, and 40.5 parts of thionyl chloride was stirred for 10 min. at room temperature and for 15 min. at reflux temperature. The reaction mixture was evaporated and the residue was co-evaporated with methylbenzene. The residue was dried in vacuo at 60° C. for 24 hours, yielding 3.1 parts (99.9%) of 6-[chloro(3-pyridinyl)methyl]-3,4-dihydro-2(1H)-quinazolinone monohydrochloride (intermediate 39).

Provenance & Evidence