反应详情

A solution of 6 parts of intermediate 52, namely 4-[(1H-imidazol-1-yl)phenylmethyl]-2-nitrobenzonitrile, in 316 parts of methanol saturated with ammonia was hydrogenated at room temperature and normal pressure with 3 parts of Raney nickel. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was co-evaporated with a mixture of methanol and methylbenzene, yielding 4.8 parts (82.9%) of 2-amino-4-[(1H-imidazol-1-yl)phenylmethyl]benzamide (interm. 53).

1. customwas hydrogenated at room temperature
2. filtrationthe catalyst was filtered off
3. customthe filtrate was evaporated
4. additionThe residue was co-evaporated with a mixture of methanol and methylbenzene