Thiophene → HCID 19816065, compound

Participants

Reaction Steps

A mixture of 68 parts of intermediate 10, namely [3-(dimethoxymethyl)-4-nitrophenyl] phenylmethanone, 4 parts of a solution of thiophene in methanol 4%, 20 parts of calcium oxide and 474 parts of methanol was hydrogenated for 24 hours at normal pressure and room temperature with 6 parts of palladium-on-charcoal catalyst 10%. The catalyst was filtered off and the filtrate was evaporated. The residue was co-evaporated with methylbenzene, yielding 59.1 parts (96.8%) of [4-amino-3-(dimethoxymethyl)phenyl] phenylmethanone (interm. 64).

Provenance & Evidence