Pyridine → HCID 19816038, compound

Participants

Reaction Steps

To a stirred and cooled (10° C.) solution of 22.1 parts of intermediate 64, namely [4-amino-3-(dimethoxymethyl)phenyl] phenylmethanone, in 147 parts of pyridine were added dropwise 12.1 parts of acetyl chloride. After stirring for 1/2 hour at 10° C. and overnight at room temperature, the reaction mixture was poured into water. The product was extracted with 2,2'-oxybispropane and dichloromethane. The combined extracts were dried, filtered and evaporated. The residue was dissolved in dichloromethane. This solution was washed successively with HCl 0.1N, ammonia and water and was then dried, filtered and evaporated, yielding 27.5 parts (100%) of N-[4-benzoyl-2-(dimethoxymethyl)phenyl]acetamide (interm. 65).

Provenance & Evidence