反应详情

5-Acetyl-2-amino-4,5,6,7-tetrahydrothiazolo-[5,4-c]pyridine (110 mg, 0.51 mmol) was dissolved in ethanol (1 ml) and treated with sodium hydroxide (15.4 mg, 0.38 mmol) in ethanol (1 ml). The solution was heated to 100° for 16 hours, then treated with additional sodium hydroxide (25.6 mg, 0.64 mmol) and heated to reflux for an additional 16 hours. Solid ammonium chloride was added, and the mixture was filtered and concentrated in vacuo. The residue was dissolved in chloroform, dried over sodium sulfate and solvent was removed, leaving the title product (67.4 mg, 0.43 mmol, 84% yield) as a yellow solid, which was used without further purification.

1. temperatureThe solution was heated to 100° for 16 hours
2. temperatureheated
3. temperatureto reflux for an additional 16 hours
4. filtrationthe mixture was filtered
5. concentrationconcentrated in vacuo
6. dissolutionThe residue was dissolved in chloroform
7. dry with materialdried over sodium sulfate and solvent
8. customwas removed