反应详情

2-Amino-5,6,7,8-tetrahydro-6-triphenylmethylpyrido-[4,3-d]pyrimidine (80 mg, 0.20 mmol) was mixed with water (0.5 ml) and acetic acid (0.5 ml) and heated on a steam bath for 5 minutes. Addition of acetone provided a homogeneous mixture. Removal of solvents gave an oil, which was purified by flash column chromatography (eluant: 89:10:1 chloroform:methanol:concentrated ammonium hydroxide) to provide the title product (24.3 mg, 0.16 mmol, 80% yield).

1. temperatureheated on a steam bath for 5 minutes
2. customprovided a homogeneous mixture
3. customRemoval of solvents
4. customgave an oil, which
5. customwas purified by flash column chromatography (eluant: 89:10:1 chloroform:methanol:concentrated ammonium hydroxide)