4-Fluorobenzenesulfonyl chloride → 1-[3-(4-Fluorophenyl)sulphonamido-propyl]-3-(2-methoxyphenoxy)-pyrrolidine hydrochloride

Participants

Reaction Steps

0.78 g (4.0 mmol) of 4-fluorophenylsulphonyl chloride in 15 ml of ether were added dropwise to a solution of 1.0 g (4.0 mmol) of 1-(3-aminopropyl)-3-(2-methoxyphenoxy)-pyrrolidine in 20 ml of anhydrous ether at 0° C. After 2 hours at room temperature, the mixture was freed from solvent in vacuo and the remaining oily residue was brought to crystallization by trituration with diethyl ether/hexane. In this manner, 1.1 g (62%) of title compound were obtained as a slightly reddish, hygroscopic solid. It melted from 50° C.

Provenance & Evidence