Chloroacetyl chloride → HCID 131711943, compound

HRID 224801Notes

Reaction equation

HRID 224801 reaction equation
[CH3:1][NH:2][C:3](=[O:16])[O:4][C:5]1[C:15]2[O:14][CH2:13][CH2:12][CH2:11][O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1.[Cl:17][CH2:18][C:19](Cl)=[O:20]>C1(C)C=CC=CC=1>[O:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([O:4][C:3](=[O:16])[NH:2][CH2:1][C:19](=[O:20])[CH2:18][Cl:17])[C:15]=2[O:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 53922044HCID 53922044, compound

Product 1

HCID 131711943HCID 131711943, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

11.2 G. of 3,4-dihydro-2H-1,5-benzodioxepin-6-yl methylcarbamate, 100 ml. of toluene and 11.3 g. of chloroacetyl chloride are refluxed for 48 hours and then the mixture is evaporated to dryness. The yellow oil which remains is recrystallized from ether/petroleum ether (40°-45° C.). There is obtained 3,4-dihydro-2H-1,5-benzodioxepin-6-yl(chloroacetyl)methylcarbamate, m.p. 63°-64° C.

Workup

  1. customthe mixture is evaporated to dryness
  2. customThe yellow oil which remains is recrystallized from ether/petroleum ether (40°-45° C.)

Sources & evidence

ORD record
ord-36318337f286476e8860b2a46a7daa69
Source dataset
uspto-grants-1980_11
Patent number
US04234598

Reaction notes

Loading…