HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Valine → Boc-L-Valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Valine | HCID 6287 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Boc-L-Valine | HCID 83693 | — |
Reaction Steps
To a solution of 10 g (0.086 mol) of valine and 3.4 g (0.086 mol) of NaDH in 250 ml of dioxan: H2O (2:1) mixture was slowly added 20.5 g (0.094 mol) of ditertbutylcarbonate at 0° C. with vigorous stirring. The reaction mixture was then stirred for another hour at room temperature, dioxan was removed under reduced pressure, and BOC-Val-OH was obtained by acidifying the mixture to a pH of 2-3. The raw product consisting of 18 g of viscous oil was obtained after evaporating the solvent from the ethyl acetate extracts.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05037883 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-4def40c5bf8548508722189367ba103c |
| Source note | uspto-grants-1991_08 |