HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131716969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | L-Alanine | HCID 5950 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | HCID 13875088 | HCID 13875088 | — |
| Reactant | N-Methacryloylalanine | HCID 22826844 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 131716969 | HCID 131716969 | — |
Reaction Steps
Using the Schotten-Bauman method of acylation, N-methacryloylalanine was prepared. Coupling of MA-Ala-OH (5.35 g; 0.034 mol) with HCl.Val-Ala-OMe (8.1 g) was performed in dimethylformamide by means of dicyclohexylcarbodiimide (7.0 g) in the presence of triethylamine (3.4 g). Recrystalization from CH2Cl2 /pentene gave 9.5 g of MA-Ala-Val-Ala-OMe.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05037883 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-bcb5bc185613447a9d7692eaeee9fa7b |
| Source note | uspto-grants-1991_08 |