HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2248049Generated: October 29, 2026
Dimethylformamide → 3,4,5-Trimethoxyphenylacetonitrile
https://huagongshe.com/reaction/2248049
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 5-(Chloromethyl)-1,2,3-trimethoxybenzene | HCID 77448 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3,4,5-Trimethoxyphenylacetonitrile | HCID 25887 | — |
Reaction Steps
3,4,5-trimethoxy benzyl chloride 7.0 g and sodium cyanide 6.3 g were dissolved into 50 ml of N,N-dimethylformamide and they were then stirred at 80° C. for 45 minutes. The temperature of the reactive liquid was then lowered down to the room temperature, 200 ml of water was added thereto and then extraction was made thrice by means of 100 of ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05037827 |
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| Source dataset | uspto-grants-1991_08 |
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| ORD ID | ord-519fbf4a0e674dd3a676eaffa2f6949e |
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| Source note | uspto-grants-1991_08 |
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