Phenethylamine → N-(2-phenylethyl)acetamide

Participants

Reaction Steps

350 ml. (3.14 mol) Acetic anhydride are added dropwise within the course of 50 minutes to a solution of 376 ml. (3.0 mol) phenethylamine in 1.5 liters toluene, the temperature thereby increasing to 68° C. The reaction mixture is heated under reflux for 1 hour, the toluene is evaporated off in a high vacuum and the residue is distilled at 1.5 mm.Hg. Yield 475 g. (97% of theory); b.p. 162°-166° C./1.5 mm.Hg; m.p. 50°-52° C.

Provenance & Evidence