(+)-1,4-Dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylic acid benzyl ester → (+)-1,4-Dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylic acid

Participants

Reaction Steps

17 g (0.0352 mole) (-)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-naphthyridine-3-carboxylic acid benzyl ester is taken up in 340 mL ethanol and hydrogenated without the use of pressure at 20° C. in the presence of 6.8 g 10% palladium/charcoal (50% moist). The catalyst is filtered off and the filtrate evaporated to dryness at 35° C. on a rotary evaporator. Yield: 15.1 g (89.2% of theory).

Provenance & Evidence