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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2248159Generated: October 29, 2026

4-Nitrophenol → 4-(1-Trifluoromethylethoxy)phenol

https://huagongshe.com/reaction/2248159

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-NitrophenolHCID 980—
Reactant1-Trifluoromethylethyl methanesulfonateHCID 15629015—
Product4-(1-Trifluoromethylethoxy)phenolHCID 19816547—

Reaction Steps

Following the above procedures, 1-trifluoromethylethyl methanesulfonate is reacted with 4-nitrophenol to give 4-(1-trifluoromethylethoxy)phenol, which is then reacted with ethyl N-(2-chloroethyl)carbamate to give ethyl N-{2-[4-(1-trifluoromethylethoxy)phenoxy]ethyl}carbamate (compound 29, Table A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05037991
Source datasetuspto-grants-1991_08
ORD IDord-9aaa45ff8b5f4186b20f1814427c8412
Source noteuspto-grants-1991_08