1-methyl-1H-pyrazol-5-amine hydrochloride → 1-Acetyl-2(1-methyl-5-pyrazolyl)amino-2-imidazoline

HRID 224817Notes

Reaction equation

HRID 224817 reaction equation
Cl.[NH2:2][C:3]1[N:7]([CH3:8])[N:6]=[CH:5][CH:4]=1.[C:9]([N:12]1[CH2:16][C:15](=O)[N:14]=[CH:13]1)(=[O:11])[CH3:10]>>[C:9]([N:12]1[CH2:16][CH2:15][N:14]=[C:13]1[NH:2][C:3]1[N:7]([CH3:8])[N:6]=[CH:5][CH:4]=1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 186898491-methyl-1H-pyrazol-5-amine hydrochlorideHCID 22350258N-acetyl-2-imidazolinone

Product 1

HCID 127637911-Acetyl-2(1-methyl-5-pyrazolyl)amino-2-imidazoline

Procedure

5-Amino-1-methyl pyrazole hydrochloride (mp 143-145, from base described in Ber. 98, 3374, 1965) (40.0 g.) and 1-acetyl-2-imidazolinone (43.0 g.) were reacted as described in Example I to give 42.4 g. product mp 158°-166° (crystallized from CH3CN)

Workup

  1. customto give 42.4 g

Sources & evidence

ORD record
ord-a2699076838f48318b890cb9203d5535
Source dataset
uspto-grants-1980_11
Patent number
US04234594

Reaction notes

Loading…