Sodium Hydroxide → HCID 15662551, compound

Participants

Reaction Steps

To a solution of the above phthalimide (6.84 g, 19.7 mmol) in 100 mol of ethanol, heated to 60°, is added hydrazine hydrate (2.0 ml, 41.0 mmol) with stirring. Additional ethanol (100 ml) is added and the mixture is stirred overnight at 60°. After cooling, 5% sodium hydroxide is added and the basic mixture is extracted with ether. The combined organic layers are washed with water and brine, dried and rotoevaporated to give 2-[4-(1-methylpropylthio)phenoxy]ethylamine.

Provenance & Evidence