N-acetyl-2-imidazolinone → 1-Acetyl-2[1-(2-chlorophenyl)-5-pyrazolyl] amino-2-imidazoline

HRID 224823Notes

Reaction equation

HRID 224823 reaction equation
Cl.[NH2:2][C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])[N:6]=[CH:5][CH:4]=1.[C:15]([N:18]1[CH2:22][C:21](=O)[N:20]=[CH:19]1)(=[O:17])[CH3:16]>>[C:15]([N:18]1[CH2:22][CH2:21][N:20]=[C:19]1[NH:2][C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])[N:6]=[CH:5][CH:4]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 22350258N-acetyl-2-imidazolinoneHCID 705924785-Amino-1(2-chlorophenyl) pyrazole hydrochloride

Product 1

HCID 127637931-Acetyl-2[1-(2-chlorophenyl)-5-pyrazolyl] amino-2-imidazoline

Procedure

5-Amino-1(2-chlorophenyl) pyrazole hydrochloride (Farmaco, 22, 68, 1967) (20.5 g.) and 1-acetyl-2-imidazolinone (12.6 g.) were reacted as described in Example I to give 17.11 g. product mp 179°-181° (crystallized from CH3CN)

Workup

  1. customto give 17.11 g

Sources & evidence

ORD record
ord-4f6452528ba74780978d45e7d7cd1fd8
Source dataset
uspto-grants-1980_11
Patent number
US04234594

Reaction notes

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