HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Phenylethyl)chromone → 1'-hydroxy-2,3-dihydro-6-fluoro-2-(2-propyl)-spiro-(4H-1-benzopyran-4,3'-pyrrolidine)-2'-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Phenylethyl)chromone | HCID 441964 | — |
| Reactant | 1'-benzyloxy-2,3-dihydro-6-fluoro-2-(2-propyl)-spiro-(4H-1-benzopyran-4,3'-pyrrolidine)-2'one | HCID 19094437 | — |
| Reactant | 2,3-dihydro-6-fluoro-2-propyl-4H-1-benzopyran-4-one | HCID 19094463 | — |
| Product | 1'-hydroxy-2,3-dihydro-6-fluoro-2-(2-propyl)-spiro-(4H-1-benzopyran-4,3'-pyrrolidine)-2'-one | HCID 19094440 | — |
Reaction Steps
Prepared from 2,3-dihydro-6-fluoro-2-propyl-4H-1-benzopyran-4-one via the intermediacy of the more polar diastereomer of 1'-benzyloxy-2,3-dihydro-6-fluoro-2-(2-propyl)-spiro-(4H-1-benzopyran-4,3'-pyrrolidine)-2'one (Rf=0.2, 1:1 diethyl ether/hexanes) using the same procedure for preparation of Example 7 from 2,3-dihydro-6-fluoro-2-(2-phenylethyl-4H-1-benzopyran-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05039672 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-d940d49c57ed454d8f98320043d5375b |
| Source note | uspto-grants-1991_08 |