Isopropylamine → HCID 14990558, compound

HRID 2248309Notes

Reaction equation

HRID 2248309 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].[CH3:20][CH:21]([NH2:23])[CH3:22]>O>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:23][CH:21]([CH3:22])[CH3:20])=[C:3]([N+:17]([O-:19])=[O:18])[CH:4]=2)=[O:9])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 30155644-Chloro-4'-fluoro-3-nitrobenzophenone

Product 1

HCID 14990558HCID 14990558, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 14 parts of (4-chloro-3-nitrophenyl) (4-fluorophenyl)-methanone in 69 parts of 2-propanamine was stirred overnight at reflux temperature. The reaction mixture was poured into water. The precipitate was filtered off and washed with water, dried, filtered and evaporated, yielding 14.7 parts (97.2%) of (4-fluorophenyl) [4-[(1-methylethyl)-amino]-3-nitrophenyl]methanone as a residue (int. 1).

Workup

  1. temperatureat reflux temperature
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-14fbbd2795cd443084668a93f1c7d33e
Source dataset
uspto-grants-1991_08
Patent number
US05039677

Reaction notes

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