HCID 14990558, compound → HCID 14990559, compound

HRID 2248310Notes

Reaction equation

HRID 2248310 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:12]([N+:20]([O-])=O)[CH:11]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:20][C:12]1[CH:11]=[C:10]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:9])[CH:15]=[CH:14][C:13]=1[NH:16][CH:17]([CH3:18])[CH3:19]

Participants

5

Reactant 2

HCID 14990558HCID 14990558, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14990559HCID 14990559, compoundYield 92.1%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 14.7 parts of (4-fluorophenyl) [4-[(1-methylethyl)-amino]-3-nitrophenyl]methanone in 120 parts of ethanol was hydrogenated at 2.105Pa with 3 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated, yielding 12.3 parts (92.1%) of [3-amino-4-[(1-methylethyl)amino]phenyl] (4-fluorophenyl)-methanone as a residue (int. 2).

Workup

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-b2c0c0c6e34c42298d24f57700eb1e59
Source dataset
uspto-grants-1991_08
Patent number
US05039677

Reaction notes

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