N-acetyl-2-imidazolinone → 1-Acetyl-2[1-(4-fluorophenyl)-5-pyrazolyl]amino-2-imidazoline

HRID 224832Notes

Reaction equation

HRID 224832 reaction equation
Cl.[NH2:2][C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:6]=[CH:5][CH:4]=1.[C:15]([N:18]1[CH2:22][C:21](=O)[N:20]=[CH:19]1)(=[O:17])[CH3:16]>>[C:15]([N:18]1[CH2:22][CH2:21][N:20]=[C:19]1[NH:2][C:3]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)[N:6]=[CH:5][CH:4]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 22350258N-acetyl-2-imidazolinoneHCID 233305055-Amino-1-(4-fluorophenyl)-pyrazole hydrochloride

Product 1

HCID 127637971-Acetyl-2[1-(4-fluorophenyl)-5-pyrazolyl]amino-2-imidazoline

Procedure

5-Amino-1-(4-fluorophenyl)pyrazole HCl (21 g.) and 1-acetyl-2-imidazolinone (15.4 g.) were reacted as described in Example I to give 20.76 g. product. mp 162°-164°

Workup

  1. customto give 20.76 g

Sources & evidence

ORD record
ord-774b1f56d6fd4b738b463f5cc95748b7
Source dataset
uspto-grants-1980_11
Patent number
US04234594

Reaction notes

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