HCID 19995903, compound → HCID 178478279, compound

HRID 2248349Notes

Reaction equation

HRID 2248349 reaction equation
[ClH:1].[N:2]1([CH2:7][C:8]2[CH:9]=[CH:10][C:11]3[N:15]=[N:14][N:13](O)[C:12]=3[CH:17]=2)[CH:6]=[CH:5][N:4]=[CH:3]1.[H][H]>CO>[ClH:1].[N:2]1([CH2:7][C:8]2[CH:9]=[CH:10][C:11]3[NH:15][N:14]=[N:13][C:12]=3[CH:17]=2)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 19995903HCID 19995903, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178478279HCID 178478279, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4.3 parts of 6-(1H-imidazol-1-ylmethyl)-1H-benzotriazol-1-ol monohydrochloride and 120 parts of methanol was hydrogenated at normal pressure and at 50° C. with 2 parts of platinium-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was crystallized twice from ethanol. The product was filtered off and dried, yielding 2.9 parts (72%) of 5-(1H-imidazol-1-ylmethyl)-1H-benzotriazole monohydrochloride; mp. 230.4° C. (compound 234).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. customThe residue was crystallized twice from ethanol
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-18e7b043558646efaf73c781c9c40fed
Source dataset
uspto-grants-1991_08
Patent number
US05039677

Reaction notes

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